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Basic information of Ifng :

Official Symbol of Gene Ifng
Species Mus musculus
Entrez Gene ID 15978
Official Full Name interferon gamma
Also known as Ifg; If2f; IFN-g
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000055170 AllianceGenome:MGI:107656
Map Location 10 D2; 10 66.75 cM
Drug FOXP3-EXOs treatment
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent C57BL/6 mice
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 35928722
Year 2002
Title Exosomes with FOXP3 from gene-modified dendritic cells ameliorate the development of EAE by regulating the balance of Th/Treg

Results of multiple sclerosis :

Result Moreover, the FOXP3-EXOs treatment resulted in obvious increases in the levels of regulatory T (Treg) cells and IL-10, whereas levels of T helper 1 (Th1) cells, Th17 cells, IFN-γ, IL-6, and IL-17 decreased significantly in the splenocyte culture of EAE mice.
Mechanism/pathway our findings that FOXP3-EXOs regulated Th/Treg immune homeostasis in vitro and in vivo.