Basic information of Irf1 :

Official Symbol of Gene	Irf1
Species	Rattus norvegicus
Entrez Gene ID	24508
Official Full Name	interferon regulatory factor 1
Also known as	N/A
Gene Type	protein coding
dbXrefs	AllianceGenome:RGD:2920
Map Location	10q22
Drug	treatment with MPA
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	AO rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	12203391
Year	2002
Title	Mycophenolic acid downregulates inducible nitric oxide synthase induction in astrocytes

Results of multiple sclerosis :

Result	MPA markedly inhibited IFN-β LPS-triggered astrocyte expression of mRNA for iNOS and its transcription factor IRF-1.
Mechanism/pathway	IRF-1-dependent inhibition of iNOS activation might be partly responsible for the protective effect of MPA in EAE.