Basic information of Nedd8 :

Official Symbol of Gene	Nedd8
Species	Mus musculus
Entrez Gene ID	18002
Official Full Name	neural precursor cell expressed, developmentally down-regulated gene 8
Also known as	Rub1; NEDD-8
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000010376 AllianceGenome:MGI:97301
Map Location	14 C3; 14 28.19 cM
Drug	specific inhibitor pevonedistat (MLN4924)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	33374005
Year	2021
Title	Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis

Results of multiple sclerosis :

Result	Finally, we demonstrated that inhibition of NEDD8 activating enzyme using the specific inhibitor pevonedistat (MLN4924) significantly ameliorated disease severity in murine experimental autoimmune encephalomyelitis.
Mechanism/pathway	N/A