Basic information of Ccl5 :

Official Symbol of Gene	Ccl5
Species	Mus musculus
Entrez Gene ID	20304
Official Full Name	chemokine (C-C motif) ligand 5
Also known as	SISd; Scya5; RANTES; TCP228; MuRantes
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000035042 AllianceGenome:MGI:98262
Map Location	11 C; 11 50.66 cM
Drug	IL-4 therapy(The ependymal route to cytokine-gene therapy)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	AB/H mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	11525938
Year	2001
Title	The ependymal route to the CNS: an emerging gene-therapy approach for MS

Results of multiple sclerosis :

Result	In the therapeutic protocol, the protection is owing to an in situ downregulation of expression of pro-inflammatory chemokines[e.g. monocyte chemoattractant protein 1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES)] and cytokines (e.g. IL-1β and TNF-α).
Mechanism/pathway	In turn, downregulation of expression of these chemokines and cytokines deactivates macrophages already recruited within the CNS, possibly through the activation of resident microglia.