Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	IL-4 therapy(The ependymal route to cytokine-gene therapy)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	AB/H mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	11525938
Year	2001
Title	The ependymal route to the CNS: an emerging gene-therapy approach for MS

Results of multiple sclerosis :

Result	In the therapeutic protocol, the protection is owing to an in situ downregulation of expression of pro-inflammatory chemokines[e.g. monocyte chemoattractant protein 1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES)] and cytokines (e.g. IL-1β and TNF-α).
Mechanism/pathway	In turn, downregulation of expression of these chemokines and cytokines deactivates macrophages already recruited within the CNS, possibly through the activation of resident microglia.