Basic information of Tnfrsf1a :

Official Symbol of Gene	Tnfrsf1a
Species	Mus musculus
Entrez Gene ID	21937
Official Full Name	tumor necrosis factor receptor superfamily, member 1a
Also known as	FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000030341 AllianceGenome:MGI:1314884
Map Location	6 F3; 6 59.32 cM
Drug	IFN-β-treated
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	11466408
Year	2001
Title	Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes

Results of multiple sclerosis :

Result	During the recovery phase, the mRNA level of TNFR1 was also significantly increased in CNSinfiltrating cells from IFN-g treated mice compared with controls.
Mechanism/pathway	Our results further challenge the exclusive detrimental role of IFN-g in the CNS during EAE/multiple sclerosis, and indicate that CNS-confined inflammation may induce protective immunological countermechanisms leading to a faster clearance of encephalitogenic T cells by apoptosis, thus restoring the immune privilege of the CNS.