Basic information of Il17a :
| Official Symbol of Gene | Il17a |
| Species | Mus musculus |
| Entrez Gene ID | 16171 |
| Official Full Name | interleukin 17A |
| Also known as | Il17; Ctla8; IL-17; Ctla-8; IL-17A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364 |
| Map Location | 1; 1 A4 |
| Drug | IFN-β-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 29127843 |
| Year | 2018 |
| Title | IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | Th1 and Th17 cells in IFN-β-treated mice were significantly reduced, and the levels of cytokines, such as IFN-γ, IL-17, and OPN, were significantly decreased in splenocyte supernatants as well as the levels of corresponding transcription factors. |
| Mechanism/pathway | IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK, as well as the regulation of mTOR complexes. |
