Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	IFN-b treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57Bl6/SJL
Disease	N/A

Literature information of multiple sclerosis :

Pubmed ID	10845718
Year	2000
Title	Anti-inflammatory action of type I interferons deduced from mice expressing interferon beta

Results of multiple sclerosis :

Result	Analysis of the mechanisms leading to this attenuated inflammatory response showed a decrease in the serum levels of TNF-a and an inhibition of the activation of the transcription factor NF-kB in various tissues.
Mechanism/pathway	systemic administration of IFN-b might influence the response to pro-inflammatory stimuli, in particular through the antagonism of IFN-g signaling.