Basic information of Akt1 :
| Official Symbol of Gene | Akt1 |
| Species | Mus musculus |
| Entrez Gene ID | 11651 |
| Official Full Name | thymoma viral proto-oncogene 1 |
| Also known as | Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000001729 AllianceGenome:MGI:87986 |
| Map Location | 12 F1; 12 61.2 cM |
| Drug | IFN-β-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 29127843 |
| Year | 2018 |
| Title | IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK. |
| Mechanism/pathway | IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK, as well as the regulation of mTOR complexes. |
