Basic information of Nfkb1 :
| Official Symbol of Gene | Nfkb1 |
| Species | Mus musculus |
| Entrez Gene ID | 18033 |
| Official Full Name | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
| Also known as | p50; p105; NF-KB1; p50/p105; NF-kappaB; NF-kappaB1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028163 AllianceGenome:MGI:97312 |
| Map Location | 3 G3; 3 62.82 cM |
| Drug | IFN-β-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 29127843 |
| Year | 2018 |
| Title | IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Result | IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK. |
| Mechanism/pathway | IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK, as well as the regulation of mTOR complexes. |
