Basic information of Mapk8 :

Official Symbol of Gene	Mapk8
Species	Mus musculus
Entrez Gene ID	26419
Official Full Name	mitogen-activated protein kinase 8
Also known as	JNK; JNK1; Prkm8; SAPK1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000021936 AllianceGenome:MGI:1346861
Map Location	14; 14 B
Drug	IFN-β-treated
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	29127843
Year	2018
Title	IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK.
Mechanism/pathway	IFN-β inhibited downstream inflammatory cytokines through the inhibition of PI3K/AKT/NF-κB axis and p38, JNK-MAPK, as well as the regulation of mTOR complexes.