Basic information of Trem2 :

Official Symbol of Gene	Trem2
Species	Mus musculus
Entrez Gene ID	83433
Official Full Name	triggering receptor expressed on myeloid cells 2
Also known as	TREM-2; Trem2a; Trem2b; Trem2c
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000023992 AllianceGenome:MGI:1913150
Map Location	17; 17 C
Drug	T3 and Sob-AM2 treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	34375614
Year	2022
Title	TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor

Results of multiple sclerosis :

Result	Treatment of EAE mice with T3 and Sob-AM2 upregulates TREM2 expression in diseased spinal cord regions
Mechanism/pathway	T3 and sobetirome suppress pro-inflammatory cytokine production from myeloid cells and induce phagocytic behavior in microglia, both of which are phenotypes that result from activation of the TREM2 pathway.