Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
| Drug | curcumin-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 31033006 |
| Year | 2019 |
| Title | Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL/6 mouse model |
Results of multiple sclerosis :
| Result | Gene expression analyses revealed that treatment with curcumin could lead to a significant reduction in the expression levels of pro-inflammatory cytokine coding genes including IL-6, IL-17, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ as well as a significant increase in the expression level of transforming growth factor (TGF)-β (p = 0.006) as an anti-inflammatory cytokine. |
| Mechanism/pathway | curcumin prevents the nuclear factor kB-mediated transcription of inflammatory cytokines. |
