Basic information of Il17a :

Official Symbol of Gene	Il17a
Species	Mus musculus
Entrez Gene ID	16171
Official Full Name	interleukin 17A
Also known as	Il17; Ctla8; IL-17; Ctla-8; IL-17A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364
Map Location	1; 1 A4
Drug	CRAC channel blockers
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	24307733
Year	2014
Title	Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation

Results of multiple sclerosis :

Result	In support of our in vitro and ex vivo data, we observed a predominant reduction in IL-17A+ population, whereas that of IFN-g+ cells was not significantly reduced.
Mechanism/pathway	Orai1 blockers had a potent anti-inflammatory effect in vivo.