Details

Home Details


Basic information of Rorc :

Official Symbol of Gene Rorc
Species Mus musculus
Entrez Gene ID 19885
Official Full Name RAR-related orphan receptor gamma
Also known as TOR; Thor; Nr1f3; RORgamma
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000028150 AllianceGenome:MGI:104856
Map Location 3; 3 F2.1
Drug CRAC channel blockers
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent C57BL/6 mice
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 24307733
Year 2014
Title Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation

Results of multiple sclerosis :

Result The mRNA levels of RORa and RORgt were dramatically reduced, whereas those of T-bet and Foxp3 were not significantly affected.
Mechanism/pathway Orai1 blockers had a potent anti-inflammatory effect in vivo.