Basic information of Icam1 :
| Official Symbol of Gene | Icam1 |
| Species | Mus musculus |
| Entrez Gene ID | 15894 |
| Official Full Name | intercellular adhesion molecule 1 |
| Also known as | CD54; Ly-47; Icam-1; MALA-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000037405 AllianceGenome:MGI:96392 |
| Map Location | 9 A3; 9 7.69 cM |
| Drug | IGF-1/IGFBP3–treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | (PL 3 SJL)F1 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 9541512 |
| Year | 1998 |
| Title | Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3) |
Results of multiple sclerosis :
| Result | Possible mechanisms that could explain the altered disease in IGF-1/IGFBP3–treated mice included(a) IGF-1/IGFBP3 administration delayed the onset of EAE by downregulating ICAM-1 gene expression in the central nervous system. |
| Mechanism/pathway | The changes in ICAM-1 gene expression we observed may merely reflect differences in inflammatory cell infiltration, but also provide further evidence of a mechanism for retarded entry of inflammatory cells into the CNS in mice receiving IGF-1 or IGF-1/IGFBP3. |
