Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
| Drug | fingolimod-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 25732840 |
| Year | 2015 |
| Title | FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis |
Results of multiple sclerosis :
| Result | Pretreatment of bone marrow-derived DCs with fingolimod resulted in significantly less TNFα, IFN-γ and IL-10 production by 2D2 T cells. |
| Mechanism/pathway | In this study, we found that fingolimod treatment reduced the ability of MOG35–55-loaded murine DCs to prime antigen specifically naive 2D2 T cells into pro-inflammatory Th1 cells. |
