Basic information of Ifng :
| Official Symbol of Gene | Ifng |
| Species | Mus musculus |
| Entrez Gene ID | 15978 |
| Official Full Name | interferon gamma |
| Also known as | Ifg; If2f; IFN-g |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000055170 AllianceGenome:MGI:107656 |
| Map Location | 10 D2; 10 66.75 cM |
| Drug | fingolimod-treated |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL/6 |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 25732840 |
| Year | 2015 |
| Title | FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis |
Results of multiple sclerosis :
| Result | Pretreatment of bone marrow-derived DCs with fingolimod resulted in significantly less TNFα, IFN-γ and IL-10 production by 2D2 T cells. |
| Mechanism/pathway | In this study, we found that fingolimod treatment reduced the ability of MOG35–55-loaded murine DCs to prime antigen specifically naive 2D2 T cells into pro-inflammatory Th1 cells. |
