Basic information of Il10 :

Official Symbol of Gene	Il10
Species	Mus musculus
Entrez Gene ID	16153
Official Full Name	interleukin 10
Also known as	CSIF; If2a; Il-10
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
Map Location	1 E4; 1 56.89 cM
Drug	fingolimod-treated
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	25732840
Year	2015
Title	FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis

Results of multiple sclerosis :

Result	Pretreatment of bone marrow-derived DCs with fingolimod resulted in significantly less TNFα, IFN-γ and IL-10 production by 2D2 T cells.
Mechanism/pathway	In this study, we found that fingolimod treatment reduced the ability of MOG35–55-loaded murine DCs to prime antigen specifically naive 2D2 T cells into pro-inflammatory Th1 cells.