Basic information of Plp1 :

Official Symbol of Gene	Plp1
Species	Mus musculus
Entrez Gene ID	18823
Official Full Name	proteolipid protein (myelin) 1
Also known as	jp; Plp; msd; rsh; DM20; jimpy
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Map Location	X F1; X 59.1 cM
Drug	IL-1b treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	16109311
Year	2005
Title	Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes

Results of multiple sclerosis :

Result	Interestingly, both IL-1h and TNF-a markedly inhibited the expression of MOG, CNPase, and PLP but not MBP.
Mechanism/pathway	Taken together, these studies suggest that proinflammatory cytokines inhibit the expression of myelin genes in human primary oligodendrocytes through the alteration of cellular redox.