Basic information of Cnp :

Official Symbol of Gene	Cnp
Species	Mus musculus
Entrez Gene ID	12799
Official Full Name	2',3'-cyclic nucleotide 3' phosphodiesterase
Also known as	Cnp1; Cnp-1; CNPase
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000006782 AllianceGenome:MGI:88437
Map Location	11 D; 11 63.47 cM
Drug	TNF-a treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	16109311
Year	2005
Title	Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes

Results of multiple sclerosis :

Result	Interestingly, both IL-1h and TNF-a markedly inhibited the expression of MOG, CNPase, and PLP but not MBP.
Mechanism/pathway	Taken together, these studies suggest that proinflammatory cytokines inhibit the expression of myelin genes in human primary oligodendrocytes through the alteration of cellular redox.