Basic information of Tnf :

Official Symbol of Gene	Tnf
Species	Mus musculus
Entrez Gene ID	21926
Official Full Name	tumor necrosis factor
Also known as	DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798
Map Location	17 B1; 17 18.59 cM
Drug	treatment with the KCNN4 blocker
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	15770697
Year	2005
Title	Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice

Results of multiple sclerosis :

Result	Treatment with TRAM-34 reduced the level of proinflammatory cytokines IFN-γ and TNF-a.
Mechanism/pathway	A selective KCNN4 ion-channel blocker, TRAM-34, protected mice from developing EAE, a T cell mediated inflammatory disease, primarily by reducing the level of IFN-γ and TNF-a proteins in the cell infiltrated areas of the central nervous system.