Basic information of Il10 :

Official Symbol of Gene	Il10
Species	Mus musculus
Entrez Gene ID	16153
Official Full Name	interleukin 10
Also known as	CSIF; If2a; Il-10
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
Map Location	1 E4; 1 56.89 cM
Drug	G-CSF treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27771353
Year	2017
Title	G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis

Results of multiple sclerosis :

Result	G-CSF therapy reduced pro-inflammatory cytokine IL-1a, TNF-b and NO levels in brain tissue, whereas the anti-inflammatory cytokine IL-4 content was increased.
Mechanism/pathway	Increase IL-4 and IL-10 secretions, elevate a CD4+CD25+ T cell subset that inhibits inflammatory infiltration and demyelination within the CNS of EAE.