Basic information of LAG3 :

Official Symbol of Gene	LAG3
Species	Homo sapiens
Entrez Gene ID	3902
Official Full Name	lymphocyte activating 3
Also known as	CD223
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476
Map Location	12p13.31
Drug	alemtuzumab treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	RRMS patients
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	24282306
Year	2013
Title	Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

Results of multiple sclerosis :

Result	CD4 expression of the inhibitory receptors [programmed death-1 (PD-1) and lymphocyte activation gene-3 (LAG-3)] was increased 6–9 mo after alemtuzumab.
Mechanism/pathway	CD4 expansion may also be limited by upregulation of the inhibitory receptors PD-1 and LAG-3 and prolonged CD95 (Fas) expression.