Basic information of NOS2 :

Official Symbol of Gene	NOS2
Species	Homo sapiens
Entrez Gene ID	4843
Official Full Name	nitric oxide synthase 2
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000007171 MIM:163730; AllianceGenome:HGNC:7873
Map Location	17q11.2
Drug	IFN-b treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	N/A
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	12437583
Year	2002
Title	Modulation of astrocyte inducible nitric oxide synthase and cytokine expression by interferon beta is associated with induction and inhibition of interferon gamma-activated sequence binding activity

Results of multiple sclerosis :

Result	IFN-b inhibits TNF-a, iNOS and IL-6 mRNA expression induced by IL-1/IFN-c. Pre- ()16 h), co- (0 h) and post-treatment (4 h) with IFN-b relative to the timing of IL-1/IFN-c addition show that pretreatment resulted in a greater inhibition of mRNA expression.
Mechanism/pathway	human fetal astrocytes revealed that IL-1-induced TNF-a, IL-6, as well as iNOS, are regulated by type-I and type-II IFNs.