Basic information of Il17a :

Official Symbol of Gene	Il17a
Species	Mus musculus
Entrez Gene ID	16171
Official Full Name	interleukin 17A
Also known as	Il17; Ctla8; IL-17; Ctla-8; IL-17A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364
Map Location	1; 1 A4
Drug	ADMSC-SPK1 treatment
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	33423722
Year	2020
Title	[Therapeutic Effect of SPK1 Gene Transfected Adipose Derived Mesenchymal Stem Cells on Experimental Autoimmune Encephalomyelitis Mice and Its Effect on T Helper Cell 17/Regulatory T Cells Balance]

Results of multiple sclerosis :

Result	The expression level of IL-17A in mouse brain and spinal cord tissues was significantly reduced in the ADMSC group( t=10.323, P=0.013; t=7.422, P=0.008),and it was significantly lower in the ADMSC-SPK1 group than in the ADMSC group ( t=14.244, P=0.017; t=16.865, P=0.006).
Mechanism/pathway	The mechanism may be that ADMSC-SPK1 can markedly reduce the Th17/Treg cell ratio and decrease the release of related inflammatory cytokines in EAE mice.