Basic information of Il10 :

Official Symbol of Gene	Il10
Species	Rattus norvegicus
Entrez Gene ID	25325
Official Full Name	interleukin 10
Also known as	If2a; IL10X
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000004647 AllianceGenome:RGD:2886
Map Location	13q13
Drug	IL-10 therapy
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	Dark Agouti rats
Disease	MOG-EAE

Literature information of multiple sclerosis :

Pubmed ID	18835435
Year	2009
Title	Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy

Results of multiple sclerosis :

Result	This therapy is shown here to reverse inflammation induced paralysis, to reduce disease associated reduction in sensitivity to touch, to prevent the onset of allodynia, to reverse disease associated loss of body weight, and to suppress CNS glial activation associated with disease progression in this model.
Mechanism/pathway	The mechanisms by which IL-10 reduces glial activation include both transcriptional and translational actions including suppression of pro-inflammatory gene expression, upregulation of inflammatory cytokine decoy receptors, and reduction in the activation of transcription factors responsible for pro inflammatory gene activation.