Basic information of Adora1 :

Official Symbol of Gene	Adora1
Species	Mus musculus
Entrez Gene ID	11539
Official Full Name	adenosine A1 receptor
Also known as	Ri; A1R; A1AR; AA1R; ARA1; A1-AR
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000042429 AllianceGenome:MGI:99401
Map Location	1; 1 E4
Drug	Caffeine treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	mice (A1AR+/+) and mice (A1AR-/-)
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	14960625
Year	2004
Title	A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis

Results of multiple sclerosis :

Result	Caffeine treatment augmented A1AR expression on microglia, with ensuing reduction of EAE severity, which was further enhanced by concomitant treatment with the A1AR agonist,adenosine amine congener.
Mechanism/pathway	However, A1AR acti vation after its upregulation by caffeine enhances related down stream signaling pathways,suppressing proinflammatory and augmenting anti-inflammatory responses, which diminish oligo dendrocyte cytotoxicity together with maintaining the integrity of the myelin sheath and associated axon.