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Basic information of Lif :

Official Symbol of Gene Lif
Species Mus musculus
Entrez Gene ID 16878
Official Full Name leukemia inhibitory factor
Also known as N/A
Gene Type protein coding
dbXrefs Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
Map Location 11 A1; 11 2.94 cM
Drug using recombinant viruses
Interaction Type activator

Sample information of multiple sclerosis:

Descent C57BL/6 mice
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 28836399
Year 2017
Title Multiple Sclerosis Gene Therapy with Recombinant Viral Vectors: Overexpression of IL-4, Leukemia Inhibitory Factor, and IL-10 in Wharton's Jelly Stem Cells Used in EAE Mice Model

Results of multiple sclerosis :

Result WJSCs were transduced using recombinant viruses. IL-4, IL-10 and LIF overexpression were confirmed by ELISA, WB and qPCR.
Mechanism/pathway gene therapy using anti-inflammatory cytokines can be a promising approach against multiple sclerosis (MS).