Basic information of Ccl2 :

Official Symbol of Gene	Ccl2
Species	Mus musculus
Entrez Gene ID	20296
Official Full Name	chemokine (C-C motif) ligand 2
Also known as	JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000035385 AllianceGenome:MGI:98259
Map Location	11 B5; 11 49.82 cM
Drug	Allogeneic Mesenchymal Stem Cells
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	19602999
Year	2009
Title	Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	In conclu sion, allogeneic MSCs can suppress the manifestations of EAE, yet retain the potential for alloimmunization.
Mechanism/pathway	Administration of allogeneic Balb/c-derived MSCs to C57Bl/6 mice with pre-established EAE led to a significant decrease in dis ease score over time comparable to that achieved with syngeneic MSCs, and was correlated with a significant blunting of immune cell infiltration to the spinal cord and reduced circulating levels of interferon-γ (IFN-γ) and interleukin-17.