Basic information of Stat3 :

Official Symbol of Gene	Stat3
Species	Mus musculus
Entrez Gene ID	20848
Official Full Name	signal transducer and activator of transcription 3
Also known as	Aprf; 1110034C02Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000004040 AllianceGenome:MGI:103038
Map Location	11 D; 11 63.82 cM
Drug	FTY720 treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	S1PR1(S5A) mice (C57BL/6J background)
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27699272
Year	2016
Title	Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation

Results of multiple sclerosis :

Result	FTY720 treatment downregulated Th17 cell development via targeting STAT3 activation.
Mechanism/pathway	Long-term treatment with FTY720 induced significant lymphopenia and suppressed Th17 response in the peripheral immune system via downregulating STAT3 phosphorylation in both WT and S1PR1(S5A) mice.