Basic information of Cdk5 :

Official Symbol of Gene	Cdk5
Species	Mus musculus
Entrez Gene ID	12568
Official Full Name	cyclin-dependent kinase 5
Also known as	Crk6
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000028969 AllianceGenome:MGI:101765
Map Location	5 A3; 5 11.73 cM
Drug	N/A
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	C57BL/6 or B6D21 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	20937706
Year	2010
Title	Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	These data define a distinct role for Cdk5 in lymphocyte biology and suggest that inhibition of this kinase may be beneficial in the treatment of T cell–mediated inflammatory disorders.
Mechanism/pathway	T cell receptor (TCR) stimulation leads to a rapid induction of Cdk5–p35 expression that is required for T lymphocyte activation.