Basic information of Tsc22d3 :

Official Symbol of Gene	Tsc22d3
Species	Mus musculus
Entrez Gene ID	14605
Official Full Name	TSC22 domain family, member 3
Also known as	DIP; Gilz; Dsip1; Tilz3; TSC-22R
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031431 AllianceGenome:MGI:1196284
Map Location	X; X F1
Drug	HGF therapy
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6J (H-2b) female mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	25114100
Year	2014
Title	Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells

Results of multiple sclerosis :

Result	In this study,we demonstrate that systemic HGF treatment ameliorates EAE through the development of tolerogenic dendritic cells (DCs) with high expression levels of glucocorticoid-induced leucine zipper (GILZ), a transcriptional repressor of gene expression and a key endogenous regulator of the inflammatory response.
Mechanism/pathway	Altogether, these results show that by inducing GILZ in DCs, HGF reproduces the mechanism of immune regulation induced by potent immunomodulatory factors such as IL-10, TGF-b1, and glucocorticoids and therefore that HGF therapy may have potential in the treatment of autoimmune dysfunctions.