Basic information of Timp1 :

Official Symbol of Gene	Timp1
Species	Rattus norvegicus
Entrez Gene ID	116510
Official Full Name	TIMP metallopeptidase inhibitor 1
Also known as	Timp; TIMP-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000010208 AllianceGenome:RGD:621675
Map Location	Xq11
Drug	FTY720 treatment
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	Dark Agouti (DA) rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	18540945
Year	2009
Title	FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage

Results of multiple sclerosis :

Result	It decreased the matrix metalloproteinase gene MMP-9 and increased its counterregulator—tissue inhibitor of metalloproteinase, TIMP 1—resulting in a proteolytic balance that favors preservation of blood-brain-barrier(BBB)integrity.
Mechanism/pathway	resulting in a proteolytic balance that favors preservation of blood-brain-barrier (BBB) integrity.