Basic information of Lif :

Official Symbol of Gene	Lif
Species	Mus musculus
Entrez Gene ID	18678
Official Full Name	eukemia inhibitory factor
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
Map Location	11 A1; 11 2.94 cM
Drug	LIFNano-CD4
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL / 6 mice
Disease	progressive course of EAE, and a relapsing, remitting disease course

Literature information of multiple sclerosis :

Pubmed ID	35047909
Year	2021
Title	Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic “LIF” Into the Brain: Preclinical Proof of Concept

Results of multiple sclerosis :

Result	The efficacy and speed of LIFNano-CD4 in partially reversing paralysis starting as early as 4 days was unexpected.A significant dose-dependent effect on rate of recovery from the induced relapse that was dependent on the LIF cargo increased the recovery rate which is a hallmark of neuro-protection.In marked contrast, in those mice receiving LIFNano-CD4, plasma GM-CSF was significantly reduced.
Mechanism/pathway	LIF switches CD4 cells away from myelin-directed TH17 toward Treg, able to support myelin repair and neuro-protection given that Treg releases endogenous LIF.