Basic information of S1PR1 :
| Official Symbol of Gene | S1PR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1901 |
| Official Full Name | sphingosine-1-phosphate receptor 1 |
| Also known as | EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000170989 MIM:601974; AllianceGenome:HGNC:3165 |
| Map Location | 1p21.2 |
| Drug | Fingolimod |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | Portugal |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 36590913 |
| Year | 2022 |
| Title | Fingolimod treatment modulates PPARγ and CD36 gene expression in women with multiple sclerosis |
Results of multiple sclerosis :
| Result | No significant differences for other lipids and lipid ratios were found in patient’s post-treatment compared with pre-treatment levels.Regarding apolipoproteins, a significant increase in ApoE was found at 12 months of treatment.At 6 months, patients had higher PPARγ mRNA expression in comparison to the baseline.Higher CD36 gene expression was also observed at 6 months in comparison to baseline . |
| Mechanism/pathway | Fingolimod was the first oral disease-modifying treatment (DMT) approved in MS. Fingolimod is a synthetic sphingosine analogue which once phosphorylated to sphingosine-1-phosphate (S1P) binds to several S1P receptors (S1PR).By inducing internalization and degradation of S1PR1, phospho-FTY720 impairs this egress, resulting in a significant reduction of circulating T and B cells and infiltration in the CNS.Within circulation, S1P is mainly present in high-density lipoprotein (HDL-C), and mediates the regulatory properties of this lipoprotein in immune responses.PPARs are ligand-activated transcriptional factors involved in the regulation of lipid and glucose metabolism and adaptive and innate immunity.PPAR can regulate gene expression also by interfering with other transcriptional factors and other proteins implicated in human disease. Cluster of Differentiation 36 (CD36) is a membrane receptor upregulated by PPARγ expressed in many cells that modulates immune functions and implicated in reparative mechanisms of MS lesions. |
