Basic information of Il13 :

Official Symbol of Gene	Il13
Species	Mus musculus
Entrez Gene ID	16163
Official Full Name	interleukin 13
Also known as	Il-13
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020383 AllianceGenome:MGI:96541
Map Location	11 B1.3; 11 31.98 cM
Drug	IL-13 immune gene therapy (pCHMWS-IL-13-IRES-Pac LV plasmid)
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C57BL/6J mice
Disease	MS

Literature information of multiple sclerosis :

Pubmed ID	27685637
Year	2016
Title	Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Results of multiple sclerosis :

Result	We provide evidence that IL-13 directs the polarization of both brain-resident microglia and infiltrating macrophages towards an alternatively activated phenotype, thereby promoting the conversion of a pro-inflammatory environment toward an anti-inflammatory environment.IL-13 immune gene therapy is also able to limit lesion severity in a pre-existing inflammatory environment.
Mechanism/pathway	lentiviral vector-mediated expression of the immune-modulating cytokine interleukin 13 (IL-13) induces an alternative activation program in both microglia and macrophages conferring protection against severe oligodendrocyte loss and demyelination in the cuprizone mouse model for multiple sclerosis (MS).