Basic information of Hdac2 :

Official Symbol of Gene	Hdac2
Species	Mus musculus
Entrez Gene ID	15182
Official Full Name	histone deacetylase 2
Also known as	YAF1; Yy1bp; mRPD3; D10Wsu179e
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000019777 AllianceGenome:MGI:1097691
Map Location	10 19.44 cM; 10 B1
Drug	combining valproic acid (VPA) with thyroid hormone (T3/T4)
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Inbred DA/Kini rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	25149263
Year	2014
Title	Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats

Results of multiple sclerosis :

Result

Treatment with VPA, T3 and VPA/T3 affects encephalitogenic CD4 + T cells in vitro. Treatment of encephalitogenic CD4 + T cells with VPA, T3, and VPA/T3 prior to transfer into nave rats reduces clinical signs of EAE. Acute treatment with VPA and T4 ameliorates clinical signs of EAE in DA rats. Treatment of EAE with VPA and T4 modulates the immune response,reduces numbers of Th1 cells in the brain and less fraction of Th1 cells infiltrating the brain and modulates the immune response and modulates immune response in peripheral tissues,prevents inflammatory demyelination in the brain.

Mechanism/pathway

HDAC inhibition can modulate encephalitogenic CD4 + T cells.One of the mechanisms by which treatment with VPA and the T3 precursor might be acting in the brain is by promoting oligodendrocyte lineage progression. Our data indicate that an acute treatment with VPA and T4 after the onset of EAE can produce persistent clinically relevant therapeutic effects by limiting the pathogenic immune reactions while promoting myelin gene expression.