Basic information of Shh :

Official Symbol of Gene	Shh
Species	Mus musculus
Entrez Gene ID	20423
Official Full Name	sonic hedgehog
Also known as	Hx; Dsh; Hhg1; Hxl3; ShhNC; M100081; 9530036O11Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000002633 AllianceGenome:MGI:98297
Map Location	5 B1; 5 14.39 cM
Drug	Niaspan
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	18778774
Year	2008
Title	Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

Results of multiple sclerosis :

Result	Compared to the controls, neurological functional recovery was significantly increased in the Niaspan treated mice and inflammatory infiltrates were significantly reduced , HDL level, intact myelin area, newly formed oligodendrocytes, regenerating axons,gene and protein levels of sonic hedgehog (Shh)/Gli1 were significantly increased in the Niaspan treated mice .
Mechanism/pathway	Niaspan treatment improved functional recovery after EAE, possibly, via reducing inflammatory infiltrates and demyelination areas, and stimulating oligodendrogenesis and axonal regeneration. Niaspan mediated activation of Shh/Gli1 pathway may promote functional recovery post EAE.