Basic information of Gli1 :

Official Symbol of Gene	Gli1
Species	Mus musculus
Entrez Gene ID	14632
Official Full Name	GLI-Kruppel family member GLI1
Also known as	Zfp5; Zfp-5
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000025407 AllianceGenome:MGI:95727
Map Location	10 D3; 10 74.5 cM
Drug	Niaspan
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	SJL/J mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	18778774
Year	2008
Title	Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

Results of multiple sclerosis :

Result	Compared to the controls, neurological functional recovery was significantly increased in the Niaspan treated mice and inflammatory infiltrates were significantly reduced , HDL level, intact myelin area, newly formed oligodendrocytes, regenerating axons,gene and protein levels of sonic hedgehog (Shh)/Gli1 were significantly increased in the Niaspan treated mice .
Mechanism/pathway	Niaspan treatment improved functional recovery after EAE, possibly, via reducing inflammatory infiltrates and demyelination areas, and stimulating oligodendrogenesis and axonal regeneration. Niaspan mediated activation of Shh/Gli1 pathway may promote functional recovery post EAE.