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Basic information of Mbp :

Official Symbol of Gene Mbp
Species Rattus norvegicus
Entrez Gene ID 24547
Official Full Name myelin basic protein
Also known as Mbps
Gene Type protein coding
dbXrefs Ensembl:ENSRNOG00000016516 AllianceGenome:RGD:3054
Map Location 18q12.3
Drug MBP-Ig gene therapy(retrovirally transduced B cells)
Interaction Type inhibitor

Sample information of multiple sclerosis:

Descent B10.PL
Disease EAE

Literature information of multiple sclerosis :

Pubmed ID 15093551
Year 2004
Title A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP

Results of multiple sclerosis :

Result We observed a delayed disease onset and/or decreased severity in Ac1-11 induced EAE.
Mechanism/pathway Tolerance induction is an important way of modulating the immune response in an antigen-specific manner to potentially hinder or prevent the progression of the disease.