Basic information of MBTPS1 :
| Official Symbol of Gene | MBTPS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8720 |
| Official Full Name | membrane bound transcription factor peptidase, site 1 |
| Also known as | S1P; PCSK8; SEDKF; SKI-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000140943 MIM:603355; AllianceGenome:HGNC:15456 |
| Map Location | 16q23.3-q24.1 |
| Drug | fingolimod (FTY720) |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | N/A |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 26714756 |
| Year | 2015 |
| Title | Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation |
Results of multiple sclerosis :
| Result | We found that TCF7 expression was decreased in T cells from untreated RRMS patients (T-RRMS) compared with T cells from healthy controls (T-CTL) in both ex vivo isolated and in vitro-activated T cells. To assess whether FTY720 upregulates TCF7 expression in T cells from RRMS patients, we activated T-RRMS cells in the presence or absence of FTY720 and found higher TCF7 expression in FTY720-treated T-RRMS cells .Patients treated with FTY720 showed a significant reduction in circulating CD4 T cells.Activation of T cells in presence of FTY720 showed a less inflammatory phenotype with reduced production of IFN-γ and GZMB. |
| Mechanism/pathway | This decreased effector phenotype of FTY720-treated T cells was dependent on the upregulation of TCF-1.FTY720-induced TCF-1 downregulated the pathogenic cytokines IFN-γ and GZMB by binding to their promoter/enhancer regions and mediating epigenetic modifications. |
