Basic information of MBP :

Official Symbol of Gene	MBP
Species	Homo sapiens
Entrez Gene ID	4155
Official Full Name	myelin basic protein
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925
Map Location	18q23
Drug	attenuated strains of vaccinia virus genetically engineered to contain the entire coding sequence for human MBP (vT15)
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	C. jacchus marmosets
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	9394784
Year	1997
Title	Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein

Results of multiple sclerosis :

Result	The onset of clinical EAE after immunization (pi) was markedly delayed in vT15-vaccinated animals compared to vAbT249-vaccinated controls. Proliferative responses against MBP but not against vaccinia antigens or phytohemagglutinin were suppressed in protected animals.
Mechanism/pathway	Development of attenuated live viruses carrying genes for myelin antigens could be useful for induction of immunologic tolerance and for modulation of autoimmune demyelination.