Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
| Drug | Efavirenz (NNRTI) |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | Caucasian |
| Disease | MS |
Literature information of multiple sclerosis :
| Pubmed ID | 30740110 |
| Year | 2019 |
| Title | Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus? |
Results of multiple sclerosis :
| Result | Only Efavirenz (NNRTI) decreased the expression of MSRV/HERV-Wenv at the highest concentration.Similarly, HERV-W/HERV-WEnv protein showed by FC a trend of reduction in the presence of 1 μM of combined drugs. |
| Mechanism/pathway | Activation of autoimmune processes in MS results from the interaction of genetic and environmental factors.An additional risk factor that has been identified is the expression of human endogenous retroviruses (HERVs) of the HERV-W family. |
