Basic information of Ms4a1 :
| Official Symbol of Gene | Ms4a1 |
| Species | Mus musculus |
| Entrez Gene ID | 12482 |
| Official Full Name | membrane-spanning 4-domains, subfamily A, member 1 |
| Also known as | Cd20; Ly-44; Ms4a2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024673 AllianceGenome:MGI:88321 |
| Map Location | 19 A; 19 8.19 cM |
| Drug | ocrelizumab |
| Interaction Type | inhibitor |
Sample information of multiple sclerosis:
| Descent | C57BL / 6 |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 30194232 |
| Year | 2018 |
| Title | Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease |
Results of multiple sclerosis :
| Result | Compared with naive mice, B cell repletion occurred overall faster and more simultaneously throughout the various compartments in the context of an active immunization.After the last anti-CD20 treatment, B cells proliferated in spleen and lymph nodes.Preventive anti-CD20 treatment reduced the severity of MOG protein1–117-induced EAE.Repletion of B cells in purely T cell-mediated EAE dampened the preceding disease exacerbation mediated by anti-CD20 treatment. |
| Mechanism/pathway | systemic anti-CD20 reduced the frequency of B cells in bone marrow, lymph nodes, and the spleen;abrogation of potent B cell APC function. |
