Basic information of Csf1 :

Official Symbol of Gene	Csf1
Species	Rattus norvegicus
Entrez Gene ID	78965
Official Full Name	colony stimulating factor 1
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000018659 AllianceGenome:RGD:621063
Map Location	2q34
Drug	GW2580
Interaction Type	inhibitor

Sample information of multiple sclerosis:

Descent	Dark agouti (DA)
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	27846891
Year	2016
Title	Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis

Results of multiple sclerosis :

Result

A delay in the appearance of the neurological disability was observed in the EAE + GW2580 group. A significant reduction of the severity of the disease was observed in the EAE + GW2580 group.The EAE + GW2580 animals did not show any relapse phase and after the acute phase, they were recovering till the 18 DPI, last day of the experiment. A decrease was observed in the EAE + GW2580 groups from 2 DPI compared to the GW2580 animals, which is the same profile of the body weight loss observed in the EAE group but less severe, in close correspondence with the evolution of the symptoms of the disorder, which is followed by a recovery.

Mechanism/pathway

The tyrosine kinase activity of CSF1R was inhibited by the oral administration of GW2580. GW2580 is a highly selective inhibitor of the c-FMS kinase, and through this pathway, this small molecule blocks CSF1 signaling.