Basic information of Il10 :
| Official Symbol of Gene | Il10 |
| Species | Mus musculus |
| Entrez Gene ID | 16153 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; If2a; Il-10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537 |
| Map Location | 1 E4; 1 56.89 cM |
| Drug | amyloid fibrils |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | C57BL / 6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 26621719 |
| Year | 2015 |
| Title | Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease |
Results of multiple sclerosis :
| Result | In gain-of-function experiments, B-1a cells, adoptively transferred to μMT mice with EAE, restored their therapeutic efficacy when Amylin 28–33 was administered.Stimulation of adoptively transferred bioluminescent MΦs and B-1a cells by amyloid fibrils resulted in rapid trafficking of both cell types to draining lymph nodes.Analysis of gene expression indicated that the fibrils activated the CD40/B-cell receptor pathway in B-1a cells and induced a set of immune-suppressive cell-surface proteins, including BTLA, IRF4, and Siglec G.These mechanisms culminate in reduction of paralytic signs of EAE. |
| Mechanism/pathway | The fibrils activate B-1a cells and F4/80+ MΦs, resulting in their migration to the lymph nodes, where IL-10 and cell-surface receptors associated with immune-suppression limit antigen presentation and T-cell activation. |
