Basic information of Il27 :

Official Symbol of Gene	Il27
Species	Mus musculus
Entrez Gene ID	246779
Official Full Name	interleukin 27
Also known as	p28; Il30; IL-27; IL27-A; IL-27-A; IL-27p28
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000044701 AllianceGenome:MGI:2384409
Map Location	7; 7 F3
Drug	IL-27
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	female C57BL/6 mice
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	17709543
Year	2007
Title	Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis

Results of multiple sclerosis :

Result	Animals that received IL-27-treated DLN cells showed significantly delayed onset of disease, reduced severity, and enhanced recovery compared with the control group.Release of IL-17 from Ag-specific cells was significantly suppressed in the IL-27-treated group (Fig. 4D).
Mechanism/pathway	IL-27 significantly inhibited both nonpolarized and IL-23-driven IL-17 production by myelin-reactive T cells thereby suppressing their encephalitogenicity in adoptive transfer EAE.