Basic information of Mog :

Official Symbol of Gene	Mog
Species	Rattus norvegicus
Entrez Gene ID	24558
Official Full Name	myelin oligodendrocyte glycoprotein
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000000775 AllianceGenome:RGD:3102
Map Location	20p12
Drug	DNA vaccines encoding MOG(91-108)
Interaction Type	activator

Sample information of multiple sclerosis:

Descent	LEW.1AV1, LEW.1N,DA rats
Disease	EAE

Literature information of multiple sclerosis :

Pubmed ID	12574345
Year	2003
Title	Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response

Results of multiple sclerosis :

Result	In all investigated rat strains DNA vaccination suppressed clinical signs of EAE.In CNS-derived lymphocytes, Fas ligand expression was down-regulated in DNA-vaccinated rats compared with controls.However, MOG-specific IgG2b responses were enhanced after DNA vaccination.
Mechanism/pathway	Deoxyribonucleic acid vaccination can induce Ag-specific CD4+, CD8+ and CTL responses that are protective against infectious disease. DNA vaccination can also protect from autoimmune disease.EAE is an animal model of multiple sclerosis (MS) and can be induced in rodents by myelin oligodendrocyte glycoprotein (MOG).