Basic information of Ifng :
| Official Symbol of Gene | Ifng |
| Species | Mus musculus |
| Entrez Gene ID | 15978 |
| Official Full Name | interferon gamma |
| Also known as | Ifg; If2f; IFN-g |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000055170 AllianceGenome:MGI:107656 |
| Map Location | 10 D2; 10 66.75 cM |
| Drug | IFN-γ primed WJ-MSCs |
| Interaction Type | activator |
Sample information of multiple sclerosis:
| Descent | female C57BL/6 mice |
| Disease | EAE |
Literature information of multiple sclerosis :
| Pubmed ID | 27697286 |
| Year | 2016 |
| Title | The effect of transplanted human Wharton's jelly mesenchymal stem cells treated with IFN-γ on experimental autoimmune encephalomyelitis mice |
Results of multiple sclerosis :
| Result | Leukocyte infiltration and symptoms were significantly reduced in IFN-γ primed WJ-MSCs treated group compared to other groups.These cells showed significantly reduced proliferation and increased Treg cells as well as decreased secretion and gene expression of inflammatory cytokines in EAE mice. |
| Mechanism/pathway | IFN-γ may be used to stimulate the immunomodulatory property of WJ-MSCs in clinical situations. |
